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B-25 Free Communication/Poster-Training/Detraining: MAY 30, 2007 1: 00 PM - 6: 00 PM ROOM: Hall E

Effect of a 2-Month Detraining on Glucose Tolerance and Insulin Sensitivity in Athletes- link to Adrenal Steroid Hormones

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Board #75 May 30 3:30 PM - 5:00 PM

Wang, Chin-Hua

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Medicine & Science in Sports & Exercise: May 2007 - Volume 39 - Issue 5 - p S248
doi: 10.1249/01.mss.0000273944.68691.ba
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PURPOSE: To determine whether alteration in insulinemia, due to abstention from regular exercise training, is associated with changes in serum dehydroepiandrosterone sulfate (DHEA-S) and cortisol.

METHODS: 18 highly trained badminton players (21.2±0.32 years) were enrolled into a 2-month detraining study. Fasting serum insulin, glucose, DHEA-S, and cortisol were determined at trained state and at day 60 of detraining. Glucose tolerance and insulin sensitivity were assessed by an oral glucose tolerance test (OGTT).

RESULTS: The 2-month detraining increased fasting glucose and insulin concentrations and body weight slightly, but did not significantly affect glucose tolerance and insulin response curve, in which 10 subjects had increased and 8 subjects had slightly decreased in the area under curve for insulin (IAUC). In the subjects with increased IAUC, serum cortisol was also elevated (from 0.44±0.07 to 0.83±0.26 U/L, P < 0.05) in parallel and serum creatine kinase (CK) was unaltered during detraining. Whereas in the subjects with decreased IAUC, serum cortisol (from 0.51 ±0.19 to 0.54±0.14 U/L, no significance) was not changed and serum creatine kinase (from 461± 179 to 151±21 U/L) was decreased during detraining.

CONCLUSIONS: Two groups of detrained subjects exhibited a similar reduction in serum DHEA-S levels and slight elevation in body weight. The novel finding of the study is that the changes in serum cortisol, but not DHEA-S, were associated with the change in insulin sensitivity during early phase of lifestyle change from physically active to sedentary, and this response appears to be varied individually among athletes.

© 2007 American College of Sports Medicine