A-37 Free Communication/Poster -Weight Loss: MAY 30, 2007 7:30 AM - 12:30 PM ROOM: Hall E
PURPOSE: This study compared common measures for risk of coronary heart disease (CHD) (Framingham Risk Score, TC/HDL, WHR, waist circumference) before and after weight loss in healthy overweight and obese men and women.
METHODS: 206 healthy non-smoking men and women (age 49.4±9.9, weight 108.0±21.5 kg, BMI 37.8±6.4 kg/m2) participated in 6-months of a weight management program. Participants consumed a very low-energy diet for 12 weeks followed by a maintenance diet for the duration of the study. Participants met weekly and received instruction for behavior, physical activity (PA), and nutrition as it related to weight management. Lab and blood assessments were performed at baseline and 6 months.
RESULTS: For men, body weight was significantly reduced from 124.2±21.0 to 97.7±16.1 kg and for women 101.9±19.0to 82.5±17.11 kg after 6 months. After controlling for age, men (n=56) had a Framingham Risk Score (FRS), used to estimate 10 year CHD risk, of 5.4±4.9% that was reduced to 3.7±5.7% (p=0.002), a TC/HDL of 4.0±1.1 that was reduced to 3.8±0.9 (p=0.23), a WHR of 0.96±0.08 that was reduced to 0.91±0.10 (p<0.001), and a waist circumference of 121.4±12.0 cm that was reduced to 101.1±12.0 cm (p<0.0001) after 6 months. After controlling for age, the women (n=150) had a FRS of 3.0±6.3% that was reduced to 2.5±6.0% (p=0.02), a TC/HDL of 3.9±1.0 that increased to 4.0±1.0 (p=0.60), a WHR of 0.80±0.1 that was reduced to 0.79±0.06 (p=0.40), and a waist circumference of 103.1±13.7 cm that was reduced to 89.5±13.5 (p<0.001) after 6 months.
CONCLUSIONS: For otherwise healthy non-smoking overweight or obese men, significant weight loss resulted in maintaining or reducing risk to the “low” category for each risk measure. For otherwise healthy non-smoking overweight or obese women TC/HDL and waist circumference remained slightly above the “low” risk category after weight loss. As these participants were healthy, greater reductions in these risk measures may occur with weight loss in less healthy populations such as individuals who smoke or those with diabetes.