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Resistance Training Mediated Improvement of Inflammatory Biomarkers in Overweight Eumenorrheic Women: 1786Board # 159 4:00 PM – 5:00 PM

Olson, Thomas P.; Schmitz, Kathryn H. FACSM; Leon, Arthur S. FACSM; Dengel, Donald R. FACSM

Medicine & Science in Sports & Exercise: May 2006 - Volume 38 - Issue 5 - p S288
Wednesday Afternoon Poster presentations Posters displayed from 1:00–6:00 pm. One-hour author presentation times are staggered from 2:00–3:00 pm., 3:00–4:00 pm., and 4:00–5:00 pm.: B-31 Free Communication/Poster – Strength Testing and Training: WEDNESDAY, MAY 31, 2006 2:00 PM – 5:00 PM: ROOM: Hall B

University of Minnesota, Minneapolis, MN.

PURPOSE: Overweight individuals often demonstrate elevated levels of inflammatory and cell adhesion molecules implicated in the pathogenesis of cardiovascular disease. Although aerobic exercise has been shown to improve specific biomarkers of inflammation and cell adhesion, little is known regarding the effects of resistance training (RT) on these biomarkers. This study examined the effects of one-year of RT on biomarkers of inflammation and adhesion in healthy, overweight, eumenorrheic women.

METHODS: Twenty-eight overweight (body mass index 25–35 kg/m2) women, aged 25–44 yrs were randomized to either RT or control (CTL) groups (16 RT, 12 CTL) and studied at baseline and after one-year. C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were measured by standard enzyme-linked immunosorbent assays. Body composition, blood pressure, fasting blood lipids, glucose, and insulin also were assessed.

RESULTS: There were no significant differences between the groups at baseline for any of the measured variables. The RT group demonstrated a significant improvement in one-repetition maximum bench press following one-year of RT with no significant change in the CTL group (RT=37±2 vs 40±2 kg, p <0.05; CTL=37±2 vs 36±2 kg). Analysis of variance demonstrated no significant interaction for mean arterial blood pressure (p=0.33), total cholesterol (p=0.22), low-density lipoprotein cholesterol (p=0.25), high-density lipoprotein cholesterol (p=0.24), glucose (p=0.28), or insulin (p=0.94) levels in the groups after one-year. Although there also was no significant change in body mass (p=0.14) or fat mass (p=0.58) in either group there was a significant increase in lean body mass in the RT group as compared to the CTL group (RT=42±2 vs 44±1 kg, p <0.05; CTL=40±2 vs 41 ±2 kg). There was no significant change in IL-6 in either group after one year (p=0.14), however both CRP (3.3±0.1 vs 3.0±0.1 mg/L, p <0.01) and adiponectin (3.8±0.1 vs 3.9±0.0 ug/mL, p <0.01) demonstrated significant improvements in the RT group, with no significant change in the CTL group. With this, there were no significant changes ICAM-1, VCAM-1, or E-selectin in either group.

CONCLUSIONS This study demonstrates that resistance training significantly improves inflammatory markers without affecting cell adhesion molecules in overweight but otherwise healthy women.

© 2006 American College of Sports Medicine