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Regional Fat Deposition, Cardiorespiratory Fitness and Insulin Resistance in Adult Survivors of Childhood Leukemia: 1451Board #90 11:30 AM – 12:30 AM

Janiszewski, Peter M.; Kuk, Jennifer L.; Oeffinger, Kevin C.; Church, Timothy S.; Ross, Robert

Medicine & Science in Sports & Exercise: May 2006 - Volume 38 - Issue 5 - p S203–S204
Wednesday Morning Poster Presentations: Posters displayed from 7:30 a.m.–12:30 p.m. One-hour author presentation times are staggered from 9:30–10:30 a.m., 10:30–11:30 a.m., and 11:30 a.m.–12:30 p.m.: A-27 Free Communication/Poster – Diabetes and Metabolic Risk WEDNESDAY, MAY 31, 2006 9:30 AM – 12:30 PM ROOM: Hall B

1Queen 's University, Kingston, ON, Canada.

2University of Texas Southwestern Medical Center, Dallas, TX.

3Cooper Institute, Dallas, TX.


BACKGROUND: Young adult survivors of childhood acute lymphoblastic leukemia (ALL) are at heightened risk for obesity, insulin resistance (IR), and reduced cardiorespiratory fitness (CRF). Specific fat depots, including visceral and abdominal subcutaneous adipose tissue (VAT and SAT), as well as fat stored in the liver have emerged as strong correlates of IR. Whereas in the general population CRF has been shown to attenuate the association between obesity and metabolic risk, whether or not this is true in ALL survivors remains unknown.

PURPOSE: To determine the effects of CRF and regional fat deposition on IR in young adult ALL survivors.

METHODS: VAT, SAT and liver fat were quantified by computed tomography in

45 female (age: 23.8 ± 5.3 yr) and 39 male (age: 23.2 ± 4.6 yr) ALL survivors. Liver fat was assessed by the ratio of mean liver to spleen attenuation (CTL/CTS). IR was measured by the homeostasis assessment model (HOMA).

RESULTS: Controlled for age, both CRF and VAT (p <0.05), but not liver fat (p >0.05), were significant correlates of IR in men and women ALL survivors. In a stepwise regression, VAT was the only significant predictor of IR to enter the model in both sexes (p <0.05).

CONCLUSION: In young adult ALL survivors both CRF and VAT are associated with IR. However, in both men and women VAT is the strongest predictor of IR. As physical activity is known to reduce VAT and improve CRF, these results underscore the need to increase physical activity levels in the long-term treatment of young adult ALL survivors.

Supported by NCI (100474–01), CIHR, and Heart and Stroke Foundation of Canada.

© 2006 American College of Sports Medicine