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Reduced Functional Capacity of Renal Transplant Recipients as a Major Modifiable Risk Factor in Coronary Artery Disease (CAD) Risk Status: 2553Board#61 2:00 PM – 3:00 PM

Morandi, Nicole; Garber, Carol Ewing FACSM; Bostom, Andrew; Gohh, Reginald

Medicine & Science in Sports & Exercise: May 2006 - Volume 38 - Issue 5 - p S481
Friday Afternoon Poster Presentations: Posters displayed from 1:00–6:00 p.m.: One-hour author presentation times are staggered from 2:00–3:00 p.m., 3:00–4:00 p.m., and 4:00–5:00 p.m.: F-25 Free Communication/Poster - Clinical Exercise Testing II: FRIDAY, JUNE 2, 2006 2:00 PM – 5:00 PM: ROOM: Hall B

1Northeastern University, Boston, MA.

2Brown Medical School, Providence, RI.


PURPOSE: The purpose of this study was to compare the exercise responses and functional capacity of renal transplant patients to normative predicted values.

METHODS: The subjects of this study were renal transplant patients (RTR) with no contraindications to exercise testing. Subjects underwent a maximal cycle ergometer test, anthropometric measurements, and a health assessment. Heart rate (HR), oxygen uptake (VO2), and minute ventilation (Ve) were measured during exercise. Oxygen pulse (O2P), and body mass index (BMI) were calculated.

RESULTS: The 9 female and 18 male RTR had a mean age of 43±9 years, a BMI 26.9 ± 6, and were > 6 months post transplant. The RTR had a significantly lower peak VO2 (18.52 ± 7.4 mL/kg/min; p=0.001), HR (135±23.5; p=0.001), O2P (11.5 ± 3.7 mL/bpm; p=0.01), and Ve (59.76±20.6 L/min; p=0.022), compared with normal predicted peak values (VO2: 33.83±7.2 mL/kg/min, HR:176±9.6 bpm; O2P: 15.07±3.7 mL/b, Ve: 76.79±17.8 L/min).

CONCLUSIONS: These results extend previous research in select subjects showing that renal transplant patients have a reduced exercise capacity when compared with the general population. Further work to evaluate methods to improve cardiorespiratory fitness in this high-risk population is needed.

© 2006 American College of Sports Medicine