Thursday Morning Poster Presentations: Posters displayed from 7:30 a.m.–12:30 p.m.: One-hour author presentation times are staggered from 8:30–9:30 a.m. and 9:30–10:30 a.m.: D-31 Free Communication/Poster – Supplements: THURSDAY, JUNE 1, 2006 2:00 PM – 5:00 PM ROOM: Hall B
PURPOSE: To investigate the effect of DHEA supplementation on glucose tolerance and insulin sensitivity in middle-aged women during resistive training.
METHODS: Twenty middle-aged women voluntarily participated in a 1-week resistive training program. Subjects were randomly divided into two groups: exercise-trained (E, placebo) and exercise-trained with DHEA supplementation (ED, 100 mg per day). An oral glucose tolerance test and insulin response were measured. Blood creatine kinase (CK), TNF-?, and TNF-? receptor (TNF-R) were also determined before and after the resistive training.
RESULTS: Exercise training significantly improved glucose tolerance in both E (P <0.05) and ED group (P <0.05), and DHEA supplementation facilitated this training response (P <0.05). The resistive training program significantly elevated blood TNF-a (24.2±0.68 to 36.9±1.38 U/L, P <0.05) and CK levels (100±20 U/L to 156±19 U/L, P <0.05), and both increases were completely eliminated by DHEA supplementation (CK:100±20vs. 83±11 U/L, TNF-α: 26.3±0.25 vs. 26.6±0.17 U/L).
CONCLUSIONS: The current study reveals that DHEA provides a protective effect for middle-aged women from potential muscle damage resulting from resistive training. This protective effect appears to enhance the training-induced improvement in glucose tolerance.