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Effects of DHEA Supplementation on Middle-aged Adults During Resistive Training: 2248Board #185 3:00 PM – 4:00 PM

Yang, Sun-Chin; Liao, Yi-Hung; Wu, Po-Chih; Huang, Yi-Jen; Kuo, Chia-Hua; Ivy, John L. FACSM, FACSM

Medicine & Science in Sports & Exercise: May 2006 - Volume 38 - Issue 5 - p S405
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1Vanung University, Taoyuan, Taiwan Republic of China.

2Taipei Physical Education College, Taipei, Taiwan Republic of China.

3Soochow University, Taipei, Taiwan Republic of China.


PURPOSE: To investigate the effect of DHEA supplementation on glucose tolerance and insulin sensitivity in middle-aged women during resistive training.

METHODS: Twenty middle-aged women voluntarily participated in a 1-week resistive training program. Subjects were randomly divided into two groups: exercise-trained (E, placebo) and exercise-trained with DHEA supplementation (ED, 100 mg per day). An oral glucose tolerance test and insulin response were measured. Blood creatine kinase (CK), TNF-?, and TNF-? receptor (TNF-R) were also determined before and after the resistive training.

RESULTS: Exercise training significantly improved glucose tolerance in both E (P <0.05) and ED group (P <0.05), and DHEA supplementation facilitated this training response (P <0.05). The resistive training program significantly elevated blood TNF-a (24.2±0.68 to 36.9±1.38 U/L, P <0.05) and CK levels (100±20 U/L to 156±19 U/L, P <0.05), and both increases were completely eliminated by DHEA supplementation (CK:100±20vs. 83±11 U/L, TNF-α: 26.3±0.25 vs. 26.6±0.17 U/L).

CONCLUSIONS: The current study reveals that DHEA provides a protective effect for middle-aged women from potential muscle damage resulting from resistive training. This protective effect appears to enhance the training-induced improvement in glucose tolerance.

© 2006 American College of Sports Medicine