Arterial stiffness and endothelial dysfunction have been attributed to the pathogenesis of atherosclerosis. Many non-invasive arterial assessment techniques have been developed, yet they appear to be specific to certain geographic locations and are rarely compared in the same study.
PURPOSE: The purpose of this study was to compare arterial stiffness measures (pulse wave velocity and cardio-ankle vascular index) using three different devices Sphygmocor 2000, Complior SP, and VaSera VS-1000 to flow-mediated dilation (FMD) and intima-media thickness (IMT).
METHODS: Twenty healthy, college-aged men and women were assigned to all three modalities of arterial stiffness and tested on three separate occasions at the same time of day within a one-week interval. In addition, FMD and IMT were measured using ultrasound imaging during one of the three visits.
RESULTS: The intraclass correlation coefficient + S.E.M. for the Sphygmocor 2000, Complior SP, and VaSera VS-1000 wereR = 0.557 + 0.688, P <0.001; 0.618 + 0.689, P<0.001; 0.336 +0.657, P= 0.009 respectively. Pearson correlation coefficients indicated no significant interrelationships between the various measures of arterial function, (P <0.05).
CONCLUSIONS: The three non-invasive modalities investigated in this study may be reliable in measuring arterial stiffness but do not significantly correlate with each other, FMD, or IMT in this young, healthy population sample. Future studies with a larger sample size and a greater range of cardiovascular risk will be needed to verify these findings.