C-25: Free Communication/Poster – Circulation: VEGF and Endothelial Function: THURSDAY, JUNE 2, 2005 9:00 AM - 12:00 PM: ROOM: Ryman C2
Elevated body mass index (BMI) is a well known risk factor for the development of cardiovascular disease (CVD) and impaired endothelial function has recently been implicated as the initial step in the pathogenesis of CVD. To examine the relationship between obesity and endothelial function, we recruited overweight (BMI 25–29.9) and obese (BMI ≥ 30) pre-menopausal women without other traditional risk factors for CVD.
Twenty-two overweight (BMI=26.7 ± 0.3 kg/m2) and 19 obese (BMI=31.8 ± 0.4 kg/m2) pre-menopausal (38 ± 1 and 37 ± 1 yr, respectively) women were recruited. Body composition, blood pressure, fasting lipids and glucose were measured. Vascular structure and function were measured via non-invasive ultrasound of the carotid and brachial arteries.
As expected the overweight group had significantly lower BMI (p<0.0001), body mass (p<0.0001), lean mass (P=0.003), fat mass (p<0.0001), and % body fat (P=0.03) compared to the obese group. There was no significant difference in total cholesterol, low-density lipoprotein cholesterol, triglycerides, or fasting glucose. High-density lipoprotein cholesterol was greater in overweight than obese women (P=0.004). There was no significant difference in systolic (P=0.09), diastolic (P=0.65), or mean arterial blood pressure (P=0.27). Peak flow-mediated dilation and area under the flow-mediated dilation curve was significantly reduced in the obese group (P=0.03 and P=0.03, respectively). There was a significant association between endothelial function and BMI (r=0.32, P=0.04).
These results demonstrate a significantly impaired endothelial function in obese compared to overweight counterparts. These results underscore the important relationship between obesity and impaired endothelial function.