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Age Of Running Wheel Exposure Alters Wheel Activity Of Female Inbred Mice: 2275 Board#64 10:30AM – 12:00PM

Jung, Alan P.; Curtis, Tamera S.; Tumer, Michael J.

Medicine & Science in Sports & Exercise: May 2005 - Volume 37 - Issue 5 - p S439
G-22: Free Communication/Poster – Exercise and Chronic Illness: SATURDAY, JUNE 4, 2005 9:00 AM - 12:00 PM ROOM: Ryman C1

University of North Carolina at Charlotte, Charlotte, NC.


Although daily running wheel activity is exhibited by inbred mouse strains, it is currently unknown if the age of wheel exposure influences running wheel activity.

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To determine whether the age at which a running wheel was introduced affected running wheel activity for a subsequent 15 week period.

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Twenty female C57Bl/6J mice (age seven weeks) were assigned to one of four experimental groups (five mice per group). Group 1 received a running wheel at seven weeks of age. Thereafter, groups 2, 3, and 4 received a running wheel at 10, 13, and 16 weeks of age, respectively. Daily running wheel activity (measured as duration, distance, and velocity) was recorded from the time of running wheel exposure until 30 weeks of age.

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A repeated measures MANOVA found significant differences between groups for distance (p = 0.02), duration (p = 0.04), and velocity (p = 0.001) during the 15 week concurrent running period (age 16–30 weeks). The following table indicates mean (±SEM) values for the concurrent running period (age 16–30 weeks).



There were also significant interactions between groups over time for distance (p = 0.01) and duration (p = 0.04). Distance (p = 0.04) decreased significantly during the 15 week period. No significant difference between groups was observed for body weight over the 24 week period (p > 0.05) or over the final 15 week period (p > 0.05); however, body weight did increase significantly over time (p = 0.01).

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This data suggests that the age at which physical activity is introduced may influence the subsequent level of physical activity.

©2005The American College of Sports Medicine