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Mitochondrial Disorders: From Pathophysiology to Acquired Defects

Ennis, Gregory M. MB, ChB, Reviewer

Section Editor(s): Berry, , Michael J. Ph.D., FACSM, Book Review Editor

Medicine & Science in Sports & Exercise: August 2003 - Volume 35 - Issue 8 - p 1461

(Stanford University School of Medicine)

Mitochondrial Disorders: From Pathophysiology to Acquired Defects

Editors: Desnuelle, Claude; DiMauro, Salvatore, Bibliographic Data: (ISBN: 2-287-59759-x, Springer-Verlag, 2002, $85.00) 325 pages, hard cover. Subjects: Genetics, Neurology, General Medicine.

DESCRIPTION: This book provides a carefully considered overview of important topics in mitochondrial disease. PURPOSE: This original book broadly surveys mitochondrial medicine by synthesizing a great deal of information succinctly. There are 26 contributing authors who offer a variety of perspectives on this expanding field. AUDIENCE: A concentrated readership of physicians and scientists interested in learning about recent advances in primary or secondary dysfunction of the mitochondrial respiratory chain is anticipated. Although the book is clearly written and accessible to nonspecialists, detail is sufficient to interest researchers in the field. The editors and authors are preeminent authorities in mitochondrial disease. FEATURES: The chapters are informative reviews on topics ranging from biochemical and molecular aspects of mitochondrial biology to apoptosis and aging. The importance of the interaction between the nuclear and mitochondrial genomes is emphasized. Several chapters that illustrate specific points are written in the form of scientific articles and are interspersed with the more general reviews. The book is divided into four major sections: Part I describes mitochondrial biology; Part II is devoted to iatrogenic causes of mitochondrial dysfunction, especially antiretroviral agents, but other drugs with potential to harm mitochondria are also discussed; Part III gives an overview of mitochondrial medicine, with an emphasis on neurological features; and Part IV provides perspective on potential therapies for mitochondrial disease. Overall, the book successfully highlights the central role that mitochondria play in diverse disease processes, including cancer, diabetes, drug sensitivity, and neurodegenerative, gastrointestinal, kidney, and hematopoietic disorders. The book is very well organized. Illustrations are helpful and clear. References are current and authoritative. This book is unique in providing a truly comprehensive review of a vast and rapidly expanding field. ASSESSMENT: This book is an outstanding contribution to the field of mitochondrial medicine. This comprehensive yet concise review should be available in any medical library. SCORE: Weighted Numerical Score: 96

©2003The American College of Sports Medicine