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Wilber, R L. FACSM1; Holm, P L.1; Morris, D M.1; Dallam, G M.1; Subudhi, A W.1; Murray, D M.1; Callan, S D.1

Medicine & Science in Sports & Exercise: May 2003 - Volume 35 - Issue 5 - p S116
C-151 Free Communication/Poster Altitude and Athletic Performance

1United States Olympic Committee, Colorado Springs, CO

One method of live high-train low (LHTL) altitude training involves living in a natural, hypobaric hypoxic environment and using supplemental oxygen during training sessions for the purpose of simulating a PIO2 ≥ normoxia/sea level (159 Torr). However, using supplemental oxygen in this manner (LH + TLO2) may produce additional oxidative stress and possibly impair positive training adaptations.

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To evaluate the acute effects of supplemental oxygen (FIO2 ∼0.26, 0.60) on oxidative stress during a high-intensity interval workout in trained endurance athletes residing at moderate altitude.

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Subjects (n=19) were trained male cyclists who were residents of moderate altitude (1800–1900 m). Testing was conducted at 1860 m (PB 610–612 Torr, PIO2 ∼128 Torr). Subjects completed three randomized, single-blind trials in which they performed a standardized interval workout (6 × 100 kJ) while inspiring a medical grade gas with an FIO2 ∼0.21 (PIO2 ∼128 Torr), 0.26 (PIO2 ∼159 Torr), and 0.60 (PIO2 ∼366 Torr). A repeated measures ANOVA was used to evaluate differences in serum and urinary biomarkers of oxidative stress.

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Compared with the control trial (FIO2 ∼0.21), average total time (min: sec) for the 100-kJ work interval was 5% and 8% (p < 0.05) faster in the 0.26 and 0.60 FIO2 trials, respectively. There was a significant pre- vs. post-exercise main effect (p < 0.05) for serum lipid hydroperoxide (LOOH) and reduced glutathione (GSH); however, there were no differences in LOOH or GSH between the FIO2 trials. Urinary oxidative stress markers malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were not affected by either the interval training session or FIO2.

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These data suggest that supplemental oxygen used in conjunction with high-intensity interval training at altitude results in a significant improvement in exercise performance without inducing additional oxidative stress. Supported by the United States Olympic Committee and Oxis Research

©2003The American College of Sports Medicine