G-15N Free Communication/Poster Endocrinology
CHF patients are known to have GH resistance, resulting in lower IGF-1 levels than healthy subjects. The effect of exercise training on plasma IGF-I levels in CHF patients has not been investigated systematically.
To examine if baseline plasma IGF-I levels reflect trainability in CHF patients.
49 CHF patients (m/f=38/11, NYHA class II/III, age (mean±SD) 59±9 yr, LVEF: 27.8±7.7% (echocardiography) were randomly assigned to a training (TG) or control group (CG). According to their IGF-I levels, patients were dichotomized into a low IGF-1 group (LI: more than ISD lower than reference values) and a normal to high IGF-1 group (NHI: ≥ reference values) resulting in 4 groups: LITG, LICG, NHITG and NHICG. Training (endurance and resistance) was 4 times/wk during 26 wks. Before and after intervention IGF-1 (chemiluminescence) and exercise tolerance (incremental cycle ergometry) were assessed.
Baseline plasma IGF-I reflects the anaerobic trainability in CHF patients. In the NHI group, but not in the LI group, IGF-I levels declined significantly. We hypothesize that GHresistance in CHF is characterized by “levelling-off” of plasma IGF-I levels, and that, irrespective of training, the NHI-levels progressively decline towards LI-levels.