E19d Free Communication/Slide Multiple Sclerosis/Neuromuscular Disorders
Increased body temperature in MS can produce transient neurological signs.
Our purpose was to evaluate the effects of lower limb cooling on fatigue and motor function in MS patients with minimal (MIN; EDSS = 2.0–3.5; n = 15) or moderate (MOD; EDSS = 4.0–6.5; n = 15) disability, and healthy controls (CON; n = 10).
Subjects were cooled twice via water immersion (20 °C) to the suprailiac crest for 30 min (COOL) and 5 min (SHAM) before exercise. The following were administered before, immediately after, and 30 min after exercise for COOL and SHAM trials: 25-ft walk, 10 sec finger tap, and Fatigue Impact Scale (FIS). Exercise consisted of arm/leg ergometry at 60% VO2 peak for 30 min.
After COOL, core temperature (Trec) was −0.24, −0.12, and −0.78 °C from baseline for CON, MIN, and MOD, respectively. SHAM produced no Trec changes. Following exercise, Trec were +0.21, +0.36, and −0.24 °C from baseline after COOL, and +0.60, +0.68, and +0.55 °C from baseline after SHAM for CON, MIN, and MOD, respectively. FIS scores were significantly different at baseline (CON < MIN < MOD) for COOL and SHAM (p < 0.05). MOD exhibited significantly greater fatigue immediately postexercise with SHAM (p < 0.05). Walking deteriorated immediately postexercise for MIN and MOD for COOL and SHAM, although MOD slowed significantly more after SHAM (p < 0.05). MOD had significantly lower tapping scores at each measurement (p < 0.05). COOL did not result in improved tapping performance for any group.
Precooling attenuated Trec increases during exercise and positively influenced fatigue and function. Supported by the National Multiple Sclerosis Society