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E16P FREE COMMUNICATION/POSTER LIPID AND LIPOPROTEIN METABOLISM

ASSOCIATION BETWEEN LIPIDS AND INDICIES OF CORONARY VASCULAR COMPLIANCE IN TRAINED AND UNTRAINED SWINE

Martin, S E.1; Parker, J L.1; Mattox, M1; Fogarty, J1; Crouse, S F. FACSM1

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Medicine & Science in Sports & Exercise: May 2001 - Volume 33 - Issue 5 - p S214
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Our purpose was to examine the influence of exercise training on the relationships between plasma lipids and coronary artery vascular compliance in Yucatan miniature swine experimentally treated with chronic coronary artery occlusion {CCO}. An ameroid constrictor was surgically placed around the proximal region of the LCX coronary artery. Animals were then randomly assigned into either exercise trained {n ≡ 10} or sedentary {n ≡ 10} groups. After a two month recovery period, exercise trained animals completed a progressive treadmill training program for 12 weeks {5d/wk }. Sedentary animals were pen confined for 12 weeks. Blood samples were obtained following an overnight {10–12 hour} fast and after completion of the 12 week exercise program or period of inactivity. Plasma samples were analyzed for TC, TG, HDL-C, and HDL 3-C. HDL2-C and LDL-C were calculated. Vascular compliance of excised LAD vessel rings was assessed by measuring internal circumferential length as the rings were stretched to the optimum of the length tension curve.

Results:

Initial internal vessel circumferences were not different between the groups. Vascular compliance was significantly different between the exercise and sedentary groups as determined by t-test{p < 0.01 }. For correlation analysis within each group, Pearson's correlation coefficients were calculated. In the sedentary group, vascular compliance associated with HDL-C {r ≡ .642, P ≡ .045 }, and HDL 3-C{r ≡ .028, P ≡ .009 }. No significant associations were determined in the trained swine. Thus, our results provide evidence that exercise may have beneficial effects on vascular compliance in CCO treated swine. HDL-C and HDL 3-C are associated with measures of vascular compliance only in sedentary swine. Supported by NIH grants PO1-HL52490 and RO1-HL64931

©2001The American College of Sports Medicine