An oral antihistamine (clemastine fumarate) was evaluated on muscle swelling and other indicators of exercise-induced muscle damage. Four non-weight trained male subjects were randomized into either a placebo (PLA) or antihistamine (AH) condition in a double-blind crossover design. Dosing of either AH or PLA treatment started the day before the exercise session and continued for the next six days. Subjects performed 50 maximal eccentric actions of the elbow flexors on a modified arm curl machine. The exercise was repeated two weeks later on the contralateral arm. Measurements for evaluating muscle damage included: flexed arm angle (FANG), relaxed arm angle (RANG), maximal isometric strength (STR), upper arm circumference at a distal (DIST) and mid-bicep (MID) location, soreness upon movement (SOR) and palpation (PALP), and plasma levels of creatine kinase (CK). All measurements were taken immediately post-exercise and every 24 hours for 5 consecutive days after exercise. Criterion measures of STR, SOR, PALP, DIST, and FANG had significant and characteristic changes over time. There were no significant differences between conditions for any measure. The results of this preliminary study indicate the prophylactic use of an antihistamine showed no marked effect in reducing the markers associated with exercise-induced muscle damage.
American College of Sports Medicine; 46th Annual Meeting; Washington State; Convention & Trade Center; June 2-5, 1999
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A-33 POSTER MUSCLE INJURY I