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EFFECT OF A CHRONIC DIET SUPLEMENTATION OF ORNITHINE, CITRAULLINE AND ARGININE ON EXERCISE PERFORMANCE AND METABOLISM 486

Mendonça, J. R.*; Lancha, A. H. Jr.**; Curi, R.*

Medicine & Science in Sports & Exercise: May 1996 - Volume 28 - Issue 5 - p 82
Annual Meeting Abstracts
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Dept. Histology, *Dept. Physiology and Biophysics, **Dept. Biodynamic of Human Body Movement, University of S[horizontal bar over]ao Paulo, SP, Brazil.

    Adult male rats were submitted to swimming training (5% extra body weight attached to the tail) during 1h daily for 4 weeks. During the last week, the rats received an oral diet supplementation of arginine, citrulline and ornithine (15, 4, 1 mg/100g boby weight, respectively) and were killed at rest and after exhaustion. The results were compared with those obtained from animals that received saline under similar conditions. The supplementation raised the period of exhaustion by 72.6% (17.04 ± 2.53 for the control and 29.41 ± 3.07 min for the supplemented group, n=15). Concomitantly this finding was accompanied by a reduction in glucose (18% - from 82.9± 2.5 to 68.1 ± 3.1 mg/dL), lactate (18% - from 4.72 ± 0.25 to 3.91 ± 0.42 μM/mL), ammonia (54% - from 13.7 ± 0.28 to 6.3 ± 0.14 μg/mL) and urea (32% - from 47.5 ± 1.38 to 32.21 ± 1.40 mg/dL) and an increase in glutamine (27% - from 1422.5± 44.8 to 1804.2 ± 92.1 nmol/mL) in plasma of the supplemented group. The rate of glycogen synthesis from [U- 14C]-glucose in 1h incubated soleus muscle of sedentary rats was markedly increased (70% - from 2.40 ± 0.45 to 4.08 ± 0.51 μM/h/100g tissue) as well as the content of glycogen in the gastrocnemius muscle. These findings suggest that arginine, citrulline and ornithine are metabolized by skeletal muscles provoking significant metabolic changes such as an increase in glycogen and glutamine synthesis and a decrease in lactate and ammonia production which could lead to a better performance during exercise.

    Section Description

    D-10 SLIDE NUTRITIONAL ERGOGENIC AIDS

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