There is a paucity of information on the clustering of cardiometabolic risk factors in young adults and how this clustering may vary based on whether or not they perform sufficient levels of physical activity
We analyzed baseline data from 346 young adults (23.3±4.4 y) participating in the Healthy Body Healthy U (HBHU) clinical trial from 2015-2018. Cardiometabolic risk factors were measured according to standard procedures and moderate-to-vigorous intensity physical activity
(MVPA) was determined by accelerometry. A cardiometabolic clustering score (CCS; ranging from 0 to 5) was created from five biomarkers according to whether or not a standard clinical risk cut point was exceeded (0=no; 1=yes): abdominal circumference [>102 cm (men) or >88 cm (women)]; HbA1c (≥ 5.7%); HDL-C [<40 mg/dL (men) or <50 mg/dL (women)]; SBP (≥ 130 mmHg); and DBP (≥85 mmHg). Cardiometabolic dysregulation (CD) was defined as a CCS >
3. Multiple logistic regression determined the independent association between level of MVPA and CD, while adjusting for sex, race/ethnicity, sedentary time, and smoking.
The prevalence of CD was 18% (22% in men; 17% in women). We observed a non-linear graded association between MPA and CD. Participants performing 150-300 min/week of MVPA significantly lowered their odds of CD by 66% (OR=0.34; 95% CI=0.16, 0.75), while those exceeding 300 min/week lowered their odds by 61% (OR=0.39; 95% CI: 0.18, 0.86), compared with those performing <150 min/week, independent of obesity and the other covariables.
Recommended levels of moderate-intensity physical activity is significantly associated with a lower odds of CD and thus may prevent or diminish the need for expensive pharmaceutical treatment over the remainder of the lifespan.