This study aimed to investigate whether prospectively reallocating time away from sedentary behavior
(SB) into different physical activity
intensities is associated with 12-month change to cardiometabolic
health in a cohort at high risk
of type 2 diabetes
Participants with known risk factors for T2DM were recruited from primary care (Leicestershire, United Kingdom) as part of the Walking Away from Type 2 Diabetes
= 808). Participants were followed up at 12, 24, and 36 months. SB, light-intensity physical activity
(LPA) and moderate-to-vigorous intensity physical activity
(MVPA) were measured objectively by accelerometer
. Postchallenge glucose, triglycerides, HDL cholesterol, systolic blood pressure, and waist circumference were analyzed individually and combined into a clustered cardiometabolic
risk score (CMRS). Associations of changing SB over each consecutive 12-month period were analyzed taking account of repeated measures.
Reallocating 30 min from SB to LPA was associated with 0.21-cm (95% confidence interval, 0.03–0.38 cm) reduction in waist circumference, 0.09-mmol·L−1
) reduction in 2-h glucose, 0.02-mmol·L−1
) reduction in triglycerides, and 0.02 (0.01–0.03) reduction in CMRS. Every 30-min reallocation from SB to MVPA was associated with 1.23-cm (0.68–1.79 cm) reduction in waist circumference, 0.23-mmol·L−1
) reduction in 2-h glucose, 0.04-mmol·L−1
) reduction in triglycerides, and 0.07 (0.04–0.11) reduction in CMRS. Reallocating 30 min from LPA into MVPA was also associated with 1.02-cm (0.43–1.60 cm) reduction in waist circumference, 0.16-mmol·L−1
) reduction in 2-h glucose, and 0.05 (0.01–0.09) reduction in CMRS.
Over 12 months, reallocating time away from SB into LPA or MVPA was associated with improved cardiometabolic
health in a population at risk of T2DM, with the greatest benefits observed for MVPA.