(1) Determine the effect of exercise amount and intensity on the proportion of individuals for whom the adipose tissue (AT) response is above the minimal clinically important difference (MCID); and (2) Examine whether clinically meaningful anthropometric changes reflect individual AT responses above the MCID.
= 41) and women (n
= 62) (52.7 ± 7.6 yr) were randomized to control (n
= 20); low amount low intensity (n
= 24); high amount low intensity (n
= 30); and high amount high intensity (n
= 29) treadmill exercise for 24 wk. The AT changes were measured by MRI. 90% confidence intervals for each individual’s observed response were calculated as the observed score ±1.64 × TE (technical error of measurement).
For visceral AT, HAHI and HALI had a greater proportion of individuals whose AT change and 90% confidence interval were beyond the MCID compared to controls (P
< 0.006). For all other AT depots, all exercise groups had significantly more individuals whose changes were beyond the MCID compared with controls. Of those who achieved a waist circumference or body weight reduction ≥ the MCID, 76% to 93% achieved abdominal, abdominal subcutaneous, and visceral AT changes ≥ the MCID.
Increasing exercise amount and/or intensity may increase the proportion of individuals who achieve clinically meaningful visceral AT reductions. Waist circumference or body weight changes beyond a clinically meaningful threshold are predictive of clinically meaningful abdominal adiposity changes.