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Sedentarism, Physical Activity, Steps, and Neurotrophic Factors in Obese Children

MORA-GONZALEZ, JOSE1; MIGUELES, JAIRO H.1; ESTEBAN-CORNEJO, IRENE1,2; CADENAS-SANCHEZ, CRISTINA1; PASTOR-VILLAESCUSA, BELÉN3,4; MOLINA-GARCÍA, PABLO1,5; RODRIGUEZ-AYLLON, MARÍA1; RICO, MARÍA C.4; GIL, ANGEL4,6,7; AGUILERA, CONCEPCIÓN M.4,6,7; ESCOLANO-MARGARIT, MARÍA VICTORIA8; GEJL, ANNE KAER9; ANDERSEN, LARS BO10; CATENA, ANDRÉS11; ORTEGA, FRANCISCO B.1

Medicine & Science in Sports & Exercise: November 2019 - Volume 51 - Issue 11 - p 2325–2333
doi: 10.1249/MSS.0000000000002064
APPLIED SCIENCES
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Purpose This study aimed to examine the associations of sedentary time, physical activity (PA) and step-related behaviors with neurotrophic growth factors.

Methods A total of 97 children with overweight/obesity age 8 to 11 yr participated in this study. Sedentary time, PA, and steps were measured by GT3X+ accelerometers in hip and nondominant wrist. Estimates of light, moderate, vigorous, and moderate-to-vigorous PA (MVPA) were obtained. Steps per daytime, peak 60-, 30-, and 1-min cadence were computed. The time accumulated (min·d−1) in different cadence bands of steps was also computed from hip accelerometer. Plasma levels of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin growth factor-1 (IGF-1) were determined by the XMap technology (Luminex IS 100/200 system, Luminex Corporation, Austin, TX).

Results Light PA, moderate PA, MVPA, and the peak 60-min cadence were positively related with BDNF concentrations (all P < 0.05), and only light PA to VEGF (P = 0.048). No association was observed for IGF-1 (P > 0.05). The associations of light PA with BDNF and VEGF disappeared (all P > 0.05) after performing analyses with nondominant wrist-placement data. However, moderate PA and MVPA remained significantly associated with BDNF (both P < 0.05). The time accumulated in cadence bands of 40 to 59 steps per day and 60 to 79 steps per day (i.e., walking at slow pace) was positively associated with plasma BDNF (all P < 0.05).

Conclusions In conclusion, PA is positively related to plasma BDNF, whereas no relationship was observed for VEGF or IGF-1. Higher amounts of time spent in slow walking cadence bands could increment BDNF levels. Exercise-based randomized controlled trials in children with overweight/obesity should be carried out to better understand the influence of PA behaviors on the neurotrophic factors.

1PROFITH “PROmoting FITness and Health through physical activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sports Science, University of Granada, Granada, SPAIN

2Department of Psychology, Northeastern University, Boston, MA

3LMU - Ludwig-Maximilians-Universität München, Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children’s Hospital, University of Munich Medical Center, Munich, GERMANY

4Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology “José Mataix,” Center of Biomedical Research, University of Granada, Granada, SPAIN

5Department of Rehabilitation Sciences, KU Leuven – University of Leuven, Leuven, BELGIUM

6Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, SPAIN

7CIBER Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Madrid, SPAIN

8Hospital Universitario San Cecilio, Granada, SPAIN

9Department of Physiotherapy and Occupational Therapy, University College Copenhagen, Copenhagen, DENMARK

10Western Norway University of Applied Sciences, Campus Sogndal, Faculty of Education, Arts and Sport, NORWAY

11Department of Experimental Psychology, Mind, Brain and Behaviour Research Centre (CIMCYC), University of Granada, Granada, SPAIN

Address for correspondence: Jose Mora-Gonzalez, M.Sc., Department of Physical and Sports Education, Faculty of Sports Science, University of Granada; Carretera de Alfacar, 21. Granada 18071, Spain; E-mail: jmorag@ugr.es.

Submitted for publication December 2018.

Accepted for publication May 2019.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.acsm-msse.org).

Online date: June 14, 2019

© 2019 American College of Sports Medicine