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Women Experience the Same Ergogenic Response to Caffeine as Men

SKINNER, TINA L.1; DESBROW, BEN2,3; ARAPOVA, JULIA1; SCHAUMBERG, MIA A.1,4; OSBORNE, JOHN1,5; GRANT, GARY D.3,6; ANOOPKUMAR-DUKIE, SHAILENDRA3,6; LEVERITT, MICHAEL D.1

Medicine & Science in Sports & Exercise: June 2019 - Volume 51 - Issue 6 - p 1195–1202
doi: 10.1249/MSS.0000000000001885
APPLIED SCIENCES
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Purpose This study aimed to determine whether 1) consumption of caffeine improves endurance cycling performance in women and 2) sex differences exist in the magnitude of the ergogenic and plasma responses to caffeine supplementation.

Methods Twenty-seven (11 women and 16 men) endurance-trained cyclists and triathletes participated in this randomized, double-blind, placebo-controlled, crossover study. Participants completed an incremental exercise test to exhaustion, two familiarization trials, and two performance trials. Ninety minutes before the performance trials, participants ingested opaque capsules containing either 3 mg·kg−1 body mass of anhydrous caffeine or a placebo. They then completed a set amount of work (75% of peak sustainable power output) in the fastest possible time. Plasma was sampled at baseline, preexercise, and postexercise for caffeine. Strict standardization and verification of diet, hydration, training volume and intensity, and contraceptive hormone phase (for women) were implemented.

Results Performance time was significantly improved after caffeine administration in women (placebo: 3863 ± 419 s, caffeine: 3757 ± 312 s; P = 0.03) and men (placebo: 3903 ± 341 s, caffeine: 3734 ± 287 s; P < 0.001). The magnitude of performance improvement was similar for women (mean = 4.3%, 95% CI = 0.4%–8.2%) and men (4.6%, 2.3%–6.8%). Plasma caffeine concentrations were similar between sexes before exercise, but significantly greater in women after exercise (P < 0.001).

Conclusions Ingestion of 3 mg·kg−1 body mass of caffeine enhanced endurance exercise performance in women. The magnitude of the performance enhancement observed in women was similar to that of men, despite significantly greater plasma caffeine concentrations after exercise in women. These results suggest that the current recommendations for caffeine intake (i.e., 3–6 mg·kg−1 caffeine before exercise to enhance endurance performance), which are derived almost exclusively from studies on men, may also be applicable to women.

1School of Human Movement and Nutrition Sciences, The University of Queensland, Queensland, AUSTRALIA;

2School of Allied Health Sciences, Griffith University, Queensland, AUSTRALIA;

3Menzies Health Institute Queensland, Griffith University, Queensland, AUSTRALIA;

4School of Health and Sports Sciences, University of the Sunshine Coast, Queensland, AUSTRALIA;

5School of Exercise and Nutrition Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, AUSTRALIA; and

6Quality Use of Medicines Network, School of Pharmacy and Pharmacology, Griffith University, Queensland, AUSTRALIA

Address for correspondence: Tina Skinner, Ph.D., School of Human Movement and Nutrition Sciences, The University of Queensland, St. Lucia, Queensland 4072, Australia; E-mail: t.skinner@uq.edu.au.

Submitted for publication September 2018.

Accepted for publication January 2019.

© 2019 American College of Sports Medicine