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Supraspinal Fatigue and Neural-evoked Responses in Lowlanders and Sherpa at 5050 m

RUGGIERO, LUCA; MCNEIL, CHRIS J.

Medicine & Science in Sports & Exercise: January 2019 - Volume 51 - Issue 1 - p 183–192
doi: 10.1249/MSS.0000000000001748
APPLIED SCIENCES

Purpose At high altitude, Lowlanders exhibit exacerbated fatigue and impaired performance. Conversely, Sherpa (native Highlanders) are known for their outstanding performance at altitude. Presently, there are no reports comparing neuromuscular fatigue and its etiology between Lowlanders and Sherpa at altitude.

Methods At 5050 m, nine age-matched Lowlanders and Sherpa (31 ± 10 vs 30 ± 12 yr, respectively) completed a 4-min sustained isometric elbow flexion at 25% maximal voluntary contraction (MVC) torque. Mid-minute, stimuli were applied to the motor cortex and brachial plexus to elicit a motor-evoked potential and maximal compound muscle action potential (M max), respectively. Supraspinal fatigue was assessed as the reduction in cortical voluntary activation (cVA) from prefatigue to postfatigue. Cerebral hemoglobin concentrations and tissue oxygenation index (TOI) were measured over the prefrontal cortex by near-infrared spectroscopy.

Results Prefatigue, MVC torque, and cVA were significantly greater for Lowlanders than Sherpa (79.5 ± 3.6 vs 50.1 ± 11.3 N·m, and 95.4% ± 2.7% vs 88.2% ± 6.6%, respectively). With fatigue, MVC torque and cVA declined similarly for both groups (~24%–26% and ~5%–7%, respectively). During the task, motor-evoked potential area increased more and sooner for Lowlanders (1.5 min) than Sherpa (3.5 min). The M max area was lower than baseline throughout fatigue for Lowlanders but unchanged for Sherpa. TOI increased earlier for Lowlanders (2 min) than Sherpa (4 min). Total hemoglobin increased only for Lowlanders (2 min). M max was lower, whereas TOI and total hemoglobin were higher for Lowlanders than Sherpa during the second half of the protocol.

Conclusions Although neither MVC torque loss nor development of supraspinal fatigue was different between groups, neural-evoked responses and cerebral oxygenation indices were less perturbed in Sherpa. This represents an advantage for maintenance of homeostasis, presumably due to bequeathed genotype and long-term altitude adaptations.

Integrated Neuromuscular Physiology Laboratory, Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, CANADA

Address for correspondence: Chris McNeil, Ph.D., School of Health and Exercise Sciences, Faculty of Health and Social Development, The University of British Columbia, Okanagan Campus, 133-1147 Research Road, Kelowna, British Columbia, Canada V1V 1V7; E-mail: chris.mcneil@ubc.ca.

Submitted for publication March 2018.

Accepted for publication July 2018.

© 2019 American College of Sports Medicine