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Effects of Different Doses of Physical Activity on C-Reactive Protein among Women


Medicine & Science in Sports & Exercise: April 2010 - Volume 42 - Issue 4 - p 701-707
doi: 10.1249/MSS.0b013e3181c03a2b
Basic Sciences

Elevated C-reactive protein (CRP) is associated with an increased risk of cardiovascular disease. Physical activity has been inversely associated with CRP. However, the clinical trials examining the effect of exercise training have produced conflicting results.

Purpose: The purpose of this study was to examine the influence an exercise training program on CRP in postmenopausal women.

Methods: Sedentary, overweight, or obese postmenopausal women with elevated systolic blood pressure (120-160 mm Hg; n = 464) were randomized into one of four groups: a nonexercise control or one of three aerobic exercise groups; exercise energy expenditure of 4, 8, or 12 kcal·kg−1·wk−1 (KKW) for 6 months at a training intensity of 50% of peak V˙O2.

Results: Complete data for 421 participants were available, and mean (SD) baseline CRP was 5.7 (5.5) mg·L−1, with no significant differences across groups. Although V˙O2 increased in a dose-response manner, there were no significant changes in CRP in any of the exercise intervention groups compared with the control group. Change in fitness was not associated with change in CRP, whereas change in weight was significantly associated with change in CRP.

Conclusions: Despite increasing fitness, 6 months of aerobic exercise training did not improve CRP. However, improvements in CRP were associated with reductions in weight.

1Louisiana State University, Baton Rouge, LA; 2Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA; and 3Arnold School of Public Health, University of South Carolina, Columbia, SC

Address for correspondence: Timothy S. Church, M.D., M.P.H., Ph.D., Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808-4124; E-mail:

Submitted for publication June 2009.

Accepted for publication August 2009.

©2010The American College of Sports Medicine