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Beta-blockers, exercise, and the immune system in men with coronary artery disease


Medicine & Science in Sports & Exercise: April 2002 - Volume 34 - Issue 4 - p 587-591
CLINICAL SCIENCES: Clinically Relevant

SAGIV, M., D. BEN-SIRA, and E. GOLDHAMMER. Beta-blockers, exercise, and the immune system in men with coronary artery disease. Med. Sci. Sports Exerc., Vol. 34, No. 4, pp. 587–591, 2002.

Purpose The purpose of the present study was to examine the effect of aerobic exercise training on the immune system in coronary artery disease patients treated with β-blockers.

Methods Twenty-five patients (46.1 ± 2 yr) treated with atenolol, a β-blocker agent, for 3 months before exercising were divided randomly into two groups: 15 underwent an aerobic exercise training program for 12 wk at 65–70% of their work capacity, whereas the other 10 patients served as controls.

Results After training, levels of CD4 and CD8 cells were significantly (P < 0.05) higher and concomitantly the CD4/CD8 ratio decreased significantly (P < 0.05) in the exercising group compared with the control group.

Conclusions Data suggest that coronary artery disease patients exercising aerobically at 65–70% of their work capacity gain a statistically significant higher lymphocyte T cell function as compared with their untrained counterparts.

The Sports Medicine and Rehabilitation Division, The Zinman College at Wingate, ISRAEL; and Heart Institute Bnai-Zion Haifa Medical Center, ISRAEL

Submitted for publication September 2000.

Accepted for publication August 2001.

© 2002 American College of Sports Medicine