KRAEMER, R. R., J. L. KILGORE, G. R. KRAEMER, and V. D. CASTRACANE. Growth hormone, IGF-I, and testosterone responses to resistive exercise. Med. Sci. Sports Exerc., Vol. 24, No. 12, pp. 1346–1352, 1992. It has been suggested that growth hormone (GH), testosterone (T), and insulin-like growth factor I (IGF-I) play large roles in muscle tissue growth; however, in only two investigations IGF-I responses to resistive exercise have been examined. Eight young males who had not weight trained for a minimum of 5 months participated in the study. Three sets of bench press (BP), lat-pull (LP), leg extension (LE), and leg curl (LC) exercises were performed at a 10-RM load for 10 repetitions or until failure. Blood samples were collected from an IV catheter before exercise (-30 min and −10 min), after each individual exercise (BP, LP, LE, LC), and after the exercise session (+5, +15, +25, +35, +95 min; +5:35, +22:30, and +23:30 h). GH, IGF-I, and T determinations were corrected for plasma volume change. GH significantly increased (P < 0.05), but IGF-I did not change. Correction for plasma volume accounted for significant increases in T, but did not account for GH and IGF-I results. These data suggest that moderate resistive exercise may increase GH concentrations, whereas elevated T levels can be accounted for by exercise-induced alteration of plasma volume.
