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Video Abstract for the ESSR 46.2 article “Potential Role of MicroRNA in the Anabolic Capacity of Skeletal Muscle With Aging” from author Donato Rivas. Age-induced loss of skeletal muscle mass and function, termed sarcopenia, may be the result of diminished response to anabolic stimulation. This review will explore the hypothesis that alterations in the expression of microRNA with aging contributes to reduced muscle plasticity resulting in impaired skeletal muscle adaptations to exercise-induced anabolic stimulation.