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Exercise and Sport Sciences Reviews. 45(1):24-33, January 2017
Video Abstract for the ESSR 45.1 article “Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect” from author Rob Hyldahl. Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.