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October 2018, Volume 46, Issue 4;
Video Abstract for the ESSR 46.4 article “Modulation of Energy Expenditure by Estrogens and Exercise in Women” from authors Kathleen M. Gavin, Wendy M. Kohrt, Dwight J. Klemm, and Edward L. Melanson. Reducing estrogen in women results in decreases in energy expenditure, but the mechanism(s) remain largely unknown. We postulate that the loss of estrogens in women is associated with increased accumulation of bone marrow–derived adipocytes in white adipose tissue, decreased activity of brown adipose tissue, and reduced levels of physical activity. Regular exercise may counteract the effects of estrogen deficiency.