We appreciate the interest Drs. Kerber and Turner had in our work and welcome the insightful discussion on the topic. Unfortunately, it is challenging to compare our work with the various studies released from Women’s Health Initiative because of the vast differences in the experimental approaches. Thus, it is difficult for us to specifically address most of the specific points within the letter.
With reference to the work of Dr. Karen Margolis and the contention about the “unlikely role of the visceral adipocyte,” it should be noted that body size measures (i.e., body mass index or waist circumference) are not indicators of visceral adipocyte function. We would refer both to data from two independent groups who have seen similar alterations in adipocyte function in postmenopausal women as more appropriate references with which to compare our work (2,3). In addition, we would refer both to seminal data from Drs. B. Nicklas, A. Ryan, A. Goldberg, W. Kohrt, and others whose metabolic function studies in humans produce agreeable results with those obtained from our laboratory (1,4,5).
Our review of literature argues that exercise training could be an effective intervention to prevent the onset of metabolic alterations in women experiencing estrogen dysfunction. Thus, we would suggest and encourage the use of exercise training as an intervention to avoid the complications of hormone therapy alluded to by Drs. Kerber and Turner. We appreciate the interest in our article, and we welcome further discussion.
Espen E. Spangenburg
Ana P. Valencia
Lindsay M. Wohlers
Lindsay M. Wohlers
Department of Kinesiology, University of Maryland
College Park, MD
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