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The Renin-Angiotensin System and Skeletal Muscle

Powers, Scott K.; Morton, Aaron B.; Hyatt, Hayden; Hinkley, Matthew J.

Exercise and Sport Sciences Reviews: October 2018 - Volume 46 - Issue 4 - p 205–214
doi: 10.1249/JES.0000000000000158
Perspective for Progress

The renin-angiotensin system (RAS) plays a key role in the control of blood pressure and fluid homeostasis. Emerging evidence also reveals that hyperactivity of the RAS contributes to skeletal muscle wasting. This review discusses the key role that the RAS plays in skeletal muscle wasting due to congestive heart failure, chronic kidney disease, and ventilator-induced diaphragmatic wasting.

The renin-angiotensin system plays a key role in skeletal muscle wasting due to heart failure, chronic kidney disease, and prolonged mechanical ventilation.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL

Address for correspondence: Scott K. Powers, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611-8208 (E-mail: spowers@hhp.ufl.edu).

Accepted for publication: April 17, 2018.

Editor: Roger M. Enoka, Ph.D.

© 2018 American College of Sports Medicine