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Potential Roles of Vascular Endothelial Growth Factor During Skeletal Muscle Hypertrophy

Huey, Kimberly A.

Exercise and Sport Sciences Reviews: July 2018 - Volume 46 - Issue 3 - p 195–202
doi: 10.1249/JES.0000000000000152

Vascular endothelial growth factor (VEGF) deletion in adult mouse muscle fibers contributes to impaired contractile and muscular adaptations to a hypertrophic stimulus suggesting a critical role in adult muscle growth. This review explores the hypothesis that VEGF is essential for adult muscle growth by impacting inflammatory processes, satellite-endothelial cell interactions, and contractile protein accumulation by functioning within known hypertrophic signaling pathways including insulin-like growth factor-1 (IGF-1-Akt) and Wnt-ß-catenin.

VEGF is important during adult muscle hypertrophy based on its roles in the inflammatory response, satellite-endothelial cell communication, and hypertrophic signaling pathways.

College of Pharmacy and Health Sciences, Drake University, Des Moines, IA

Address for correspondence: Kimberly A. Huey, Ph.D., College of Pharmacy and Health Sciences, Drake University, 2507 University Ave, Des Moines, IA 50311 (E-mail:

Accepted for publication: April 6, 2018.

Editor: Marni D. Boppart, Sc.D., FACSM.

© 2018 American College of Sports Medicine