We hypothesize that the reduced peak aerobic power (peak V˙O2) after heart transplantation is due to impaired cardiovascular and skeletal muscle function, and its improvement with short-term (≤1 yr) exercise training is primarily due to favorable skeletal muscle adaptations. Furthermore, the increased peak V˙O2 with long-term (>2 yr) training is primarily mediated by cardiac (sympathetic) reinnervation.
Heart transplant recipients have reduced peak V˙O2 through central and peripheral limitations. Exercise training increases peak V˙O2 via peripheral adaptations.
1College of Nursing and Health Innovation and
2Department of Kinesiology, University of Texas at Arlington, Arlington, TX;
3Department of Prevention, Rehabilitation, and Sports Medicine, Technical University Munich, Munich, Germany; and
4Cardiovascular Performance Program, Massachusetts General Hospital, Boston, MA
Address for correspondence: Mark J. Haykowsky, Ph.D., College of Nursing and Health Innovation, University of Texas at Arlington, 411 S Nedderman Dr, Arlington, TX 76010 (E-mail: firstname.lastname@example.org).
Accepted for publication: December 20, 2017.
Editor: Hirofumi Tanaka, Ph.D., FACSM.