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Circulating microRNA as Emerging Biomarkers of Exercise

Fernández-Sanjurjo, Manuel1; de Gonzalo-Calvo, David2,3,4; Fernández-García, Benjamín5,6; Díez-Robles, Sergio1; Martínez-Canal, Ángel1; Olmedillas, Hugo1,6; Dávalos, Alberto7; Iglesias-Gutiérrez, Eduardo1,6,8

Exercise and Sport Sciences Reviews: July 2018 - Volume 46 - Issue 3 - p 160–171
doi: 10.1249/JES.0000000000000148

An interest has recently emerged in the role of circulating microRNAs (c-miRNAs) as posttranscriptional regulators, intercellular communicators and, especially, as potential biomarkers of the systemic response to acute exercise and training. We propose that, with the limited, heterogeneous, and mainly descriptive information currently available, c-miRNAs do not provide a reliable biomarker of exercise in healthy or diseased individuals.

In this study we evaluate the controversial value of circulating microRNAs as biomarkers of exercise response in health and disease.

1Department of Functional Biology (Physiology), University of Oviedo, Oviedo;

2Biomedical Research Institute of Barcelona (IIBB)-CSIC;

3Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona;

4CIBERCV, Institute of Health Carlos III, Madrid;

5Department of Morphology and Cell Biology (Anatomy), University of Oviedo, Oviedo;

6Health Research Institute of the Principality of Asturias (ISPA);

7Laboratory of Epigenetics of Lipid Metabolism, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM + CSIC, Madrid, Spain; and

8Autonomous University of Chile, Santiago, Chile

Address for correspondence: Eduardo Iglesias-Gutiérrez, Ph.D., M.Sc., Department of Functional Biology (Physiology), University of Oviedo. C/Julián Clavería, s/n, 33006 Oviedo, Spain (E-mail:

Accepted for publication: December 20, 2017

Editor: Monica J. Hubal, Ph.D., FACSM

© 2018 American College of Sports Medicine