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The Renin-Angiotensin System and Skeletal Muscle

Powers, Scott K.1; Morton, Aaron1; Hyatt, Hayden1; Hinkley, Matthew J.1

doi: 10.1249/JES.0000000000000158
Perspectives for Progress: PDF Only

The renin-angiotensin system (RAS) plays a key role in the control of blood pressure and fluid homeostasis. Emerging evidence also reveals that hyperactivity of the RAS contributes to skeletal muscle wasting. This review discusses the key role that the RAS plays in skeletal muscle wasting due to congestive heart failure, chronic kidney disease, and ventilator-induced diaphragmatic wasting.

1Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida

Corresponding author: Scott K. Powers, Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611-8208, Email: spowers@hhp.ufl.edu; Telephone: 352-294-1713

This work was supported by a grant from the National Institutes of Health (NIH R01 AR064189 awarded to SKP. The authors do not have any conflicts of interest to report in regard to this work.

© 2018 American College of Sports Medicine