The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.
1School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, UK.
2Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia
Corresponding author: Andrew Philp, Ph.D. Mitochondrial Metabolism and Ageing Laboratory, Diabetes and Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia, Phone: +61 (0) 292958249 Email: email@example.com
No funding to disclose. No conflicts of interest to disclose.