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The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control

Hodson, Nathan1; Philp, Andrew1,2

doi: 10.1249/JES.0000000000000173
Brief Review: PDF Only

The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.

1School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, UK.

2Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia

Corresponding author: Andrew Philp, Ph.D. Mitochondrial Metabolism and Ageing Laboratory, Diabetes and Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia, Phone: +61 (0) 292958249 Email:

No funding to disclose. No conflicts of interest to disclose.

© 2018 American College of Sports Medicine