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Skeletal Muscle Function in The Oldest-Old: The Role of Intrinsic and Extrinsic Factors

Venturelli, Massimo1; Reggiani, Carlo2,6; Richardson, Russell, S.3,4,5; Schena, Federico1

doi: 10.1249/JES.0000000000000155
Brief Review: PDF Only

ABSTRACT Although skeletal muscle function is diminished with advanced age, single muscle fiber function appears to be preserved. Therefore, this review examines the hypothesis that the skeletal muscle fiber, per se, is not the predominant factor responsible for the reduction in force generating capacity in the oldest-old, but, rather, is attributable to a combination of factors external to the muscle fibers.

1 Department of Neurosciences, Biomedicine and Movement Sciences. University of Verona, Italy.

2 Department of Biomedical Sciences, University of Padua, Padua, Italy.

3 Division of Geriatrics, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.

4 Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.

5 Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.

6 Institute for Kinesiology Research, Science and Research Center of Koper, Koper, Slovenia

Corresponding author Massimo Venturelli, Ph.D., Department of Neurosciences, Biomedicine and Movement Sciences. University of Verona., Via Casorati 43, 37131 Verona, Italy; Phone: +39 045 8425114; e-mail:

Funding: This work was funded, in part, by the National Heart, Lung, and Blood Institute at the National Institute of Health (PO1 HL1091830) and the Veteran’s Administration Rehabilitation Research and Development Service (E6910-R, E1697-R, E1433-P, E2323-I, and E9275-L). Conflicts of interest: None

© 2018 American College of Sports Medicine