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Resistance Exercise’s Ability to Reverse Cancer-Induced Anabolic Resistance

Montalvo, Ryan N.1; Hardee, Justin P.1; VanderVeen, Brandon N.1; Carson, James A.1,2

doi: 10.1249/JES.0000000000000159
Brief Review: PDF Only

Skeletal muscle has the dynamic capability to modulate protein turnover in response to anabolic stimuli, such as feeding and contraction. We propose that anabolic resistance, the suppressed ability to induce protein synthesis, is central to cancer-induced muscle wasting. Furthermore, we propose that resistance exercise training has the potential to attenuate or treat cancer-induced anabolic resistance through improvements in oxidative metabolism.

1Department of Exercise Science, University of South Carolina, 921 Assembly Street, Public Health Research Center, Rm. 405, Columbia, SC 29208;

2Center for Colon Cancer Research, University of South Carolina, 712 Main Street, Jones PSC Bldg Rm. 614, Columbia, SC 29208

Corresponding Author: James A. Carson, PhD, rofessor & Chair, Department of Exercise Science, University of South Carolina, 921 Assembly Street, Public Health Research Center, Rm 301, Columbia, SC 29208, Phone: 803-777-2185; Email: carsonj@mailbox.sc.edu

Funding: This work was supported by National Institutes of Health Grants R01 CA121249 (National Cancer Institute) and P20 RR-017698 (National Institute of General Medical Science) to J.A.C, SPARC Graduate Research Grant from the Office of the Vice President for Research at the University of South Carolina to J.P.H, and an ACSM Foundation Research Grant from the American College of Sports Medicine Foundation to J.P.H. Conflict of interest: The authors declare no conflict of interests.

© 2018 American College of Sports Medicine