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Potential Roles of Vascular Endothelial Growth Factor During Skeletal Muscle Hypertrophy

Huey, Kimberly, A.

doi: 10.1249/JES.0000000000000152
Brief Review: PDF Only

Vascular endothelial growth factor (VEGF) deletion in adult mouse muscle fibers contributes to impaired contractile and muscular adaptations to a hypertrophic stimulus suggesting a critical role in adult muscle growth. This review will explore the hypothesis that VEGF is essential for adult muscle growth by impacting inflammatory processes, satellite-endothelial cell interactions, and contractile protein accumulation by functioning within known hypertrophic signaling pathways including insulin-like growth factor-1 (IGF-1-Akt) and Wnt-ß-catenin.

College of Pharmacy and Health Sciences, Drake University, Des Moines IA, USA

Corresponding Author: Kimberly A. Huey, Ph.D., College of Pharmacy and Health Sciences, Drake University, 2507 University Ave, Des Moines, IA 50311. Phone: 515-271-4853; email: kimberly.huey@drake.edu

This work was supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases R15AR060469 to Kimberly Huey.

Conflict of Interest: None

© 2018 American College of Sports Medicine