We hypothesize that the reduced peak aerobic power (peak VO2) following heart transplantation (HT) is due to impaired cardiovascular and skeletal muscle function, and its improvement with short-term (≤1 year) exercise training is primarily due to favorable skeletal muscle adaptations. Further, the increased peak VO2 with long-term (>2 years) training is primarily mediated by cardiac (sympathetic) reinnervation.
1College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA; 2Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA; 3Department of Prevention, Rehabilitation, and Sports Medicine, Technical University Munich, Munich, Germany; 4Cardiovascular Performance Program, Massachusetts General Hospital, Boston, MA, USA.
Corresponding Author: Mark J. Haykowsky, PhD, University of Texas at Arlington, College of Nursing and Health Innovation, 411 S Nedderman Drive, Arlington, Texas, 76010, USA. Phone: 817-272-5541; Fax: 817-272-5056; Email: email@example.com.
Disclosure of funding received for this work: None.
Disclosure of conflicts of interest: No conflicts of interest, financial or otherwise, are declared by the authors.