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Perspectives for Progress -- Performance Limitations in Heart Transplant Recipients

Tucker, Wesley, J.1,2; Beaudry, Rhys, I.1; Samuel, T., Jake2; Nelson, Michael, D.2; Halle, Martin3; Baggish, Aaron, L.4; Haykowsky, Mark, J.1

doi: 10.1249/JES.0000000000000149
Perspectives for Progress: PDF Only

ABSTRACT We hypothesize that the reduced peak aerobic power (peak VO2) following heart transplantation (HT) is due to impaired cardiovascular and skeletal muscle function, and its improvement with short-term (≤1 year) exercise training is primarily due to favorable skeletal muscle adaptations. Further, the increased peak VO2 with long-term (>2 years) training is primarily mediated by cardiac (sympathetic) reinnervation.

1College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, USA; 2Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA; 3Department of Prevention, Rehabilitation, and Sports Medicine, Technical University Munich, Munich, Germany; 4Cardiovascular Performance Program, Massachusetts General Hospital, Boston, MA, USA.

Corresponding Author: Mark J. Haykowsky, PhD, University of Texas at Arlington, College of Nursing and Health Innovation, 411 S Nedderman Drive, Arlington, Texas, 76010, USA. Phone: 817-272-5541; Fax: 817-272-5056; Email: mark.haykowsky@uta.edu.

Disclosure of funding received for this work: None.

Disclosure of conflicts of interest: No conflicts of interest, financial or otherwise, are declared by the authors.

© 2018 American College of Sports Medicine