Institutional members access full text with Ovid®

Share this article on:

Modulation of Energy Expenditure by Estrogens and Exercise in Women

Gavin, Kathleen M., PhD1,2; Kohrt, Wendy M., PhD1,2; Klemm, Dwight J.2,4; Melanson, Edward L., PhD1,2,5

doi: 10.1249/JES.0000000000000160
Brief Review: PDF Only

Reducing estrogen in women results in decreases in energy expenditure, but the mechanism(s) remain largely unknown. We postulate that the loss of estrogens in women is associated with increased accumulation of bone marrow (BM)-derived adipocytes in white adipose tissue, decreased activity of brown adipose tissue, and reduced levels of physical activity. Regular exercise may counteract the effects of estrogen deficiency.

1Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus

2Eastern Colorado VA Geriatric Research, Education, and Clinical Center

3Division of Pulmonary and Critical Care Medicine, University of Colorado Anschutz Medical Campus

4Division of Pulmonary and Critical Care Medicine, University of Colorado Anschutz Medical Campus

5Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus

Corresponding Author: Kathleen Gavin, Ph.D. MS B179, 12631 East 17th Ave, Room 8111, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, Phone: (303) 724-7472 FAX: (303) 724-1918 (Kathleen.Gavin@ucdenver.edu)

Grant support: Supported by NIH grants P50 HD073063, R01 AG018198, R01 DK112260, P30 DK048520, UL1 TR001082, and K01 DK109053. Drs. Kohrt, Klemm, and Melanson are also supported by the Geriatric Research, Education, and Clinical Center at the Denver VA Medical Center and Drs. Kohrt and Gavin are supported by the University of Colorado Center for Women’s Health Research. Conflict of Interest: The authors have no conflicts to declare

© 2018 American College of Sports Medicine