An interest has recently emerged in the role of circulating microRNAs (c-miRNAs) as posttranscriptional regulators, intercellular communicators and, especially, as potential biomarkers of the systemic response to acute exercise and training. We propose that, with the limited, heterogeneous, and mainly descriptive information currently available, c-miRNAs do not provide a reliable biomarker of exercise in healthy or diseased individuals.
1 Department of Functional Biology (Physiology), University of Oviedo, Oviedo, Spain.
2 Biomedical Research Institute of Barcelona (IIBB)-CSIC, Barcelona, Spain.
3 Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
4 CIBERCV, Institute of Health Carlos III, Madrid, Spain.
5 Department of Morphology and Cell Biology (Anatomy), University of Oviedo, Oviedo, Spain.
6 Health Research Institute of the Principality of Asturias (ISPA), Spain.
7 Laboratory of Epigenetics of Lipid Metabolism, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM+CSIC, Madrid, Spain.
8 Autonomous University of Chile, Santiago, Chile.
CORRESPONDING AUTHOR Eduardo Iglesias-Gutiérrez, PhD, MSc, Department of Functional Biology (Physiology), University of Oviedo. C/Julián Clavería, s/n, 33006 Oviedo, Spain. Phone: +34 985102793; Fax: +34 985103534; E-mail: email@example.com
FUNDING: This work was supported in part by the Ministerio de Economía y Competitividad, Spain (DEP2012-39262 to EI-G and DEP2015-69980-P to BF-G).
CONFLICTS OF INTEREST: The authors declare no conflict of interest.