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Macrophage Regulation of Muscle Regrowth From Disuse in Aging

Reidy, Paul T.1; Dupont-Versteegden, Esther E.2; Drummond, Micah J.1

Exercise and Sport Sciences Reviews: October 2019 - Volume 47 - Issue 4 - p 246–250
doi: 10.1249/JES.0000000000000201

Skeletal muscle immune cells, such as macrophages, are necessary for proper regrowth after muscle disuse. We suggest that the important role of macrophages concerning muscle regrowth after disuse is divergent compared with young mice (i.e., dysregulated) during the recovery period. Modulation of macrophages may be a promising future therapeutic target to enhance the impaired muscle growth during recovery from disuse in older adults.

We discuss the role of macrophages in the recovery of muscle after disuse or injury in aging.

1Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT

2Department of Rehabilitation Sciences, University of Kentucky, Lexington, KY

Address for correspondence: Micah J. Drummond, Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108-1213 (E-mail:

Accepted for publication: June 24, 2019.

Editor: Marni D. Boppart, Sc.D., FACSM.

Online date: July 2, 2019

© 2019 American College of Sports Medicine