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The Panacea of Human Aging

Calorie Restriction Versus Exercise

Broskey, Nicholas T.1; Marlatt, Kara L.1; Most, Jasper1; Erickson, Melissa L.1; Irving, Brian A.1,2; Redman, Leanne M.1

Exercise and Sport Sciences Reviews: July 2019 - Volume 47 - Issue 3 - p 169–175
doi: 10.1249/JES.0000000000000193
Visual Abstract

Primary aging is the progressive decline in health and fitness and depends on metabolic rate and oxidative stress. Untoward changes in body composition and metabolic function characterize secondary aging. We hypothesize that both exercise and calorie restriction (CR) improve secondary aging, but only CR improves primary. However, CR followed with exercise is a superior strategy to maintain overall health and quality of life with age.

Calorie restriction yields greater improvements than exercise in determinants of lifespan by attenuating oxidative damage.

1Pennington Biomedical Research Center, Baton Rouge, LA

2Department of Kinesiology, Louisiana State University, Baton Rouge, LA

Address for correspondence: Leanne M. Redman, Ph.D., FTOS, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 (E-mail:

Accepted for publication: March 28, 2019.

Editor: Barry Braun, Ph.D., FACSM.

Online date: April 17, 2019

© 2019 American College of Sports Medicine