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Resistance Exercise-Induced Hypertrophy

A Potential Role for Rapamycin-Insensitive mTOR

Ogasawara, Riki1,2; Jensen, Thomas E.2; Goodman, Craig A.3,4; Hornberger, Troy A.5,6

Exercise and Sport Sciences Reviews: July 2019 - Volume 47 - Issue 3 - p 188–194
doi: 10.1249/JES.0000000000000189
Journal Club

The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.

This review examines whether both rapamycin-sensitive and rapamycin-insensitive components of mTOR signaling contribute to the hypertrophic effects of resistance exercise.

1Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan;

2Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark;

3Institute of Health and Sport, Victoria University, Melbourne;

4Australian Institute for Musculoskeletal Science, Victoria University, St. Albans, Victoria, Australia;

5Department of Comparative Biosciences, and

6School of Veterinary Medicine, University of Wisconsin–Madison, Madison, WI

Address for correspondence: Riki Ogasawara, Ph.D., Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya 466-8555, Japan (E-mail:

Accepted for publication: March 5, 2019.

Editor: Marni D. Boppart, Sc.D., FACSM.

Online date: March 12, 2019

© 2019 American College of Sports Medicine