The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.
This review examines whether both rapamycin-sensitive and rapamycin-insensitive components of mTOR signaling contribute to the hypertrophic effects of resistance exercise.
1Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan;
2Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark;
3Institute of Health and Sport, Victoria University, Melbourne;
4Australian Institute for Musculoskeletal Science, Victoria University, St. Albans, Victoria, Australia;
5Department of Comparative Biosciences, and
6School of Veterinary Medicine, University of Wisconsin–Madison, Madison, WI
Address for correspondence: Riki Ogasawara, Ph.D., Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya 466-8555, Japan (E-mail: email@example.com).
Accepted for publication: March 5, 2019.
Editor: Marni D. Boppart, Sc.D., FACSM.
Online date: March 12, 2019