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Regulation of Ribosome Biogenesis During Skeletal Muscle Hypertrophy

Kim, Hyo-Gun1; Guo, Bin1; Nader, Gustavo A.1,2

Exercise and Sport Sciences Reviews: April 2019 - Volume 47 - Issue 2 - p 91–97
doi: 10.1249/JES.0000000000000179

An increase in ribosomal capacity is a hallmark of the hypertrophying muscle. We review evidence demonstrating that transcription of ribosomal RNA genes is necessary for the increase in ribosomal capacity, and this is critical for muscle growth in human and animal models of hypertrophy.

Ribosomal control of skeletal muscle hypertrophy.

1Department of Kinesiology and

2Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA

Address for correspondence: Gustavo A. Nader, Ph.D., 101 Noll Laboratory, The Pennsylvania State University, University Park, PA 16802 (E-mail:

Accepted for publication: November 29, 2018.

Editor: Benjamin F. Miller, Ph.D., FACSM.

© 2019 American College of Sports Medicine