Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Exercise and Vascular Insulin Sensitivity in the Skeletal Muscle and Brain

Olver, T. Dylan1; Laughlin, M. Harold2,3; Padilla, Jaume3,4,5

Exercise and Sport Sciences Reviews: April 2019 - Volume 47 - Issue 2 - p 66–74
doi: 10.1249/JES.0000000000000182
Perspectives for Progress

We present the hypothesis that exercise-induced hyperemia, perhaps through vascular shear stress, represents an important factor responsible for the effects of physical activity (PA) on vascular insulin sensitivity. Specifically, we postulate PA involving the greatest amount of skeletal muscle mass and the greatest central neural recruitment maximizes perfusion and consequently enhances vascular insulin sensitivity in the skeletal muscle and brain.

Physical activity–induced improvements in vascular insulin sensitivity in the skeletal muscle and brain are likely related to the exercise hyperemic response.

1Department of Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada;

2Department of Biomedical Sciences,

3Dalton Cardiovascular Research Center,

4Department of Nutrition and Exercise Physiology, and

5Department of Child Health, University of Missouri, Columbia, MO

Address for correspondence: M. Harold Laughlin, Ph.D., Department of Biomedical Sciences, Room W117, Veterinary Medicine Building, University of Missouri, Columbia, MO 65211 (E-mail:

Accepted for publication: December 5, 2018.

Editor: Philip S. Clifford, Ph.D., FACSM.

© 2019 American College of Sports Medicine