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Resistance Exercise’s Ability to Reverse Cancer-Induced Anabolic Resistance

Montalvo, Ryan N.1; Hardee, Justin P.1; VanderVeen, Brandon N.1; Carson, James A.1,2

Exercise and Sport Sciences Reviews: October 2018 - Volume 46 - Issue 4 - p 247–253
doi: 10.1249/JES.0000000000000159

Skeletal muscle has the dynamic capability to modulate protein turnover in response to anabolic stimuli, such as feeding and contraction. We propose that anabolic resistance, the suppressed ability to induce protein synthesis, is central to cancer-induced muscle wasting. Furthermore, we propose that resistance exercise training has the potential to attenuate or treat cancer-induced anabolic resistance through improvements in oxidative metabolism.

Resistance exercise training can reverse cancer-induced anabolic resistance through improved oxidative metabolism.

1Department of Exercise Science and

2Center for Colon Cancer Research, University of South Carolina, Columbia, SC

Address for correspondence: James A. Carson, Ph.D., Department of Exercise Science, University of South Carolina, 921 Assembly St, Public Health Research Center, Rm 301, Columbia, SC 29208 (E-mail:

Accepted for publication: June 6, 2018.

Editor: Stephen E. Alway, Ph.D., FACSM.

© 2018 American College of Sports Medicine