Accelerated trajectories of cognitive decline in older adults may increase the risk of developing Alzheimer disease and related dementias (ADRD). Physical activity has potential modifying effects on these changes that could prevent or delay ADRD. This review explores the hypothesis that multiple, mutually complimentary, and interacting factors explain the positive association between exercise and the optimization of cognition in older adults.
The role of physical activity and the interplay between physiological biomarkers and psychological and lifestyle factors on cognitive aging.
1Department of Physiology & Pharmacology,
2Hotchkiss Brain Institute,
3Department of Cardiac Sciences,
4Libin Cardiovascular Institute of Alberta,
5Departments of Clinical Neurosciences,
6Community Health Sciences,
8Psychology, University of Calgary;
9Psychology Service, Foothills Medical Centre, Alberta Health Services;
10Faculty of Kinesiology, University of Calgary, and
11O’Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Address for correspondence: Marc J. Poulin, Ph.D., DPhil, Department of Physiology & Pharmacology, Brenda Strafford Foundation Chair in Alzheimer Research. Cumming School of Medicine, University of Calgary HMRB-210, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada(E-mail: email@example.com).
Accepted for publication: June 21, 2018.
Editor: Demetra D. Christou, Ph.D.