Although skeletal muscle function is diminished with advanced age, single muscle fiber function seems to be preserved. Therefore, this review examines the hypothesis that the skeletal muscle fiber, per se, is not the predominant factor responsible for the reduction in force-generating capacity in the oldest-old, but, rather, is attributable to a combination of factors external to the muscle fibers.
Greatly diminished skeletal muscle function with advanced age may be a consequence of factors external to the muscle fibers.
1Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona;
2Department of Biomedical Sciences, University of Padua, Padua, Italy;
3Institute for Kinesiology Research, Science and Research Center of Koper, Koper, Slovenia;
4Division of Geriatrics, Department of Internal Medicine, University of Utah School of Medicine;
5Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center; and
6Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT
Address for correspondence: Massimo Venturelli, Ph.D., Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Via Casorati 43, 37131 Verona, Italy (E-mail: firstname.lastname@example.org).
Accepted for publication: April 4, 2018.
Editor: Roger M. Enoka, Ph.D.