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Potential Role of MicroRNA in the Anabolic Capacity of Skeletal Muscle With Aging

Margolis, Lee, M.; Rivas, Donato, A.

Exercise and Sport Sciences Reviews: April 2018 - Volume 46 - Issue 2 - p 86–91
doi: 10.1249/JES.0000000000000147
Articles
Video Abstract

Age-induced loss of skeletal muscle mass and function, termed sarcopenia, may be the result of diminished response to anabolic stimulation. This review will explore the hypothesis that alterations in the expression of microRNA with aging contributes to reduced muscle plasticity resulting in impaired skeletal muscle adaptations to exercise-induced anabolic stimulation.

Altered expression of microRNA to exercise is blunted with aging, contributing to diminished anabolic capacity of skeletal muscle and potentially sarcopenia.

Nutrition, Exercise, Physiology, and Sarcopenia Laboratory, U.S. Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA

Address for correspondence: Donato A. Rivas, Ph.D., Nutrition, Exercise, Physiology, and Sarcopenia Laboratory, U.S. Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, 711 Washington St, Boston, MA 02111 (E-mail: donato.rivas@tufts.edu).

Accepted for publication: December 7, 2017.

Associate Editor: Roger A. Fielding, Ph.D.

© 2018 American College of Sports Medicine